Young women with her2 breast cancer

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Young women with her2 breast cancer
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Published on 20-8-2017
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Women age 40 or younger diagnosed with her2-enriched disease had about the same risk of dying from breast cancer as women age 51 to 60 with the same subtype. At first the results of this study may seem hard to understand.   her2-positive breast cancer is more aggressive than other types of breast cancer. Changes in the her2 gene, can lead to cell and tumor growth, but effective treatment is available. A 2014 study of more than 4,000 women showed that trastuzumab significantly reduced recurrence and improved survival when added to chemotherapy in early stage her2-positive breast cancer.   in addition, considering both the suboptimal use of contraceptive methods among breast cancer patients as well as the apparent lack of gonadotoxicity with the administration of trastuzumab (andor lapatinib) , some physicians may need to counsel young women with her2-positive breast cancer that have become accidentally pregnant during anti-her2. Breast cancer survival in england is highest for women diagnosed aged 60-69, probably because of screening, and less favourable tumour characteristics in younger women (2009-2013). Around 9 in 10 women in england diagnosed with breast cancer between ages 40-69 survive their disease for five years or more, compared with 7 in 10 women diagnosed. Two new treatment options are emerging for women with metastatic breast cancer, following positive results from clinical trials. The trials tested the drugs tucatinib and trastuzumab deruxtecan in women who had been previously treated for metastatic breast cancer that overproduces the her2 protein, known as her2-positive breast cancer.   young women have a higher proportion of intrinsic breast cancer subtypes associated with a worse prognosis the triple-negative, her2-positive, and luminal b subtypes 5, 13, 1518. Recently, the prognostic significance of young age has been shown to differ between the different subtypes. At a time in life most often focused on family and career, issues of treatment, recovery and survivorship suddenly take top priority.

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